Thermodynamic Study on Hydrotropic Aggregation Behavior of Theophylline

Abstract: Objectives: A systematic study is required to enhance the solubility of insoluble fluid drugs that are only sparingly soluble. Hydrotropy may be a distinctive development reinforce liquid poorly water-soluble drugs. Materials and Methods: The term hydrotropic has been wont designate rise in assorted substances water because presence enormous amounts additives. Sodium salicylate, sodium benzoate, resorcinol utilized many soluble Varied organic solvents like methyl alcohol, chloroform, dimethylformamide, benzene for solubilization Theophylline drug was accessories numerous hydrotrope concentrations (0-3 mol/L) also non-inheritable sample determination analyzed an exploitation UV spectrophotometer. Results: theophylline specifically found improve with increase concentration device temperature likely close other compounds Conclusion: To initiate substantial compound, minimum (MHC) aqueous phase needed. As consequence improvement theophylline, coefficient mass transfer observed expand at 303 K. have enhancement within coefficient, threshold value equivalent MHC maintained. For all sets experiments, maximal factor, which ratio between absence hydrotrope, calculated. Thermodynamic parameters such as Gibb’s free energy, enthalpy, entropy were calculated determine aggregation activity theophylline. With system temperature, energy declines. It hydrotropes exothermic preferred by positive value. Key words: Hydrotropy, Theophylline, Solubility, Enhancement Factor, Aggregation Properties.